TRiP research group

TRiP

Stacks Image 267




Forschungsinteressen / Arbeitsschwerpunkte
Neurobiologie und Verhaltensbiologie. Molekulare Bildgebung,
Verhaltenspharmakologische, physiologische und morphologische Effekte von Psychopharmaka
Studium:
1999 bis 2006
Studium der Biologie, RWTH Aachen (Diplomarbeit: Untersuchung auditorischer Nacheffekte bei Schleiereulen (Tyto alba).
2006 bis 2012
Promotionsstudium an der Universität zu Köln in Kooperation mit dem Max-Planck-Institut für neurologische Forschung.
Dissertation:
2012
„Verhaltenspharmakologische und metabolische Untersuchungen akuter und chronischer Modulationen des Endocannabinoidsystems der Ratte“, Universität zu Köln, Naturwissenschaftliche Fakultät
Berufliche Tätigkeiten:
2006 bis 2009
Wissenschaftliche Mitarbeiterin der Klinik für Psychiatrie und Psychotherapie der Universität zu Köln
2009 bis 2018
Wissenschaftliche Mitarbeiterin am Zentralinstitut für Seelische Gesundheit Mannheim
seit 2012
Assoziierte Wissenschaftlerin, Institut für Radiochemie und Experimentelle Molekulare Bildgebung,
Medizinische Fakultät und Uniklinik Köln, Universität zu Köln, Köln
2012 to 2018
Post doc, Central Institute of Mental Health, Mannheim, Germany
seit 2018
Assoziierte Wissenschaftlerin, Arbeitsgruppe Translationale Forschung in der Psychiatrie,
Klinik für Psychiatrie und Psychotherapie, Zentralinstitut für Seelische Gesundheit Mannheim
2018 bis 2020
Research Administration Manager and Research Fellow, Brain and Mind Centre, The University of Sydney, Sydney, Australia
seit 2020
Associated Research Fellow, Brain and Mind Centre, The University of Sydney, Sydney, Australia
seit 2021
Gründerin und Geschäftsführerin, lero bioscience UG (ltd.), Bruehl, Germany


Publikationen:

  • A. Nichles, N. Zmicerevska, Y. J. C. Song, C. Wilson, C. McHugh, B. Hamilton, J. Crouse, C. Rohleder, J. S. Carpenter, N. Ho, D. F. Hermens, N. Wray, J. Scott, K. R. Merikangas, F. M. Leweke, D. Koethe, F. Iorfina, S. L. Naismith, A. J. Guastella, E. M. Scott, I. B. Hickie (2021) Neurobiology Youth Follow-up Study: protocol to establish a longitudinal and prospective research database using multimodal assessments for current and past mental health treatment-seeking young people within an early intervention service. BMJ Open 2021;11:e044731
  • A. Moldavski, H. Wenz, B. Lange, C. Rohleder, F. M. Leweke (2021) Case Report: Severe adolescent major depressive syndrome turns out to be an unusual case of Anti-NMDA receptor encephalitis. Front Psychiatry 12: 679996.
  • F. M. Leweke, C. Rohleder, C. W. Gerth, M. Hellmich, R. Pukrop, D. Koethe (2021) Cannabidiol and amisulpride improve cognition in acute schizophrenia in an explorative, double-blind, active-controlled randomized clinical trial. Front Pharmacol 12:614811.
  • C. G. Bien, C. Rohleder, J. E. Mueller, C. I. Bien, D. Koethe, F. M. Leweke (2021) Neural autoantibodies in cerebrospinal fluid and serum in clinical high risk for psychosis, first-episode psychosis, and healthy volunteers. Front Psychiatry 12:654602.
  • D. C. Schroeder, E. Popp, C. Rohleder, S. Vus, D. P. Bethencourt, S. R. Finke, B. D. Zlatopolskiy, J. Zischler, A. Drzezga, H. Herff, T. Annecke, T. Hucho, B. Neumaier, B. W. Bottiger, H. Endepols (2021) Positron Emission Tomography Imaging of Long-Term Expression of the 18 kDa Translocator Protein After Sudden Cardiac Arrest in Rats. Shock 55(5):620-629
  • A. M. Tickell, C. Rohleder, Y. J. C. Song, J. S. Carpenter, K. Harel, L. Parker, I. B. Hickie, E. Scott (2021) Protocol for a sound adult mental health (Uspace) cohort: personalising multidimensional care in young people admitted to hospital. BMJ Open 11:e038787
  • T. Woelfl, C. Rohleder, J. K. Mueller, B. Lange, A. Reuter, A. M. Schmidt, D. Koethe, M. Hellmich, F. M. Leweke (2020) Effects of cannabidiol and delta-9-tetrahydrocannabinol on emotion, cognition and attention: A double-blind, placebo-controlled, randomized experimental trial in healthy volunteers. Front Psychiatry 11:576877
  • C. Rohleder, Y. J. C. Song, J. J. Crouse, T. A. Davenport, F. Iorfino, B. Hamilton, N. Zmicerevska, A. Nichles, J. S. Carpenter, A. M. Tickell, C. Wilson, S. P. Cross, A. J. Guastella, D. Koethe, F. M. Leweke, E. M. Scott, I. B. Hickie (2020) Youth Mental Health Tracker: protocol to establish a longitudinal cohort and research database for young people attending Australian mental health services. BMJ Open 10:e035379
  • V. L. Chadwick, C. Rohleder, D. Koethe, F. M. Leweke (2020) Cannabinoids and the endocannabinoid system in anxiety, depression, and dysregulation of emotion in humans. Current Opinion in Psychiatry 33:20-42
  • Y. Bouter, M. M. Brzózka, R. Rygula, F. M. Leweke, U. Havemann-Reinecke*, C. Rohleder* (2019) Chronic psychosocial stress causes increased anxiety-like behavior and alters endocannabinoid levels in the brain in C57Bl/6J mice. Cannabis Cannabinoid Res 5:51-61
  • F. Iorfino, J. S. Carpenter, S. P. Cross, T. A. Davenport, D. F. Hermens, A. J. Guastella, C. Rohleder, J. J. Crouse, F. M. Leweke, D. Koethe, S. L. Naismith, E. M. Scott, I. B. Hickie (2019) Multidimensional outcomes in youth mental health care: what matters and why? Med J Australia 211S9:S4-S11
  • J. S. Carpenter, F. Iorfino, S. P. Cross, T. A. Davenport, D. F. Hermens, C. Rohleder, J. J. Crouse, F. M. Leweke, D. Koethe, A. J. Guastella, S. L. Naismith, J. Scott, E. M. Scott, I. B. Hickie (2019) Clinical staging pathophysiological mechanisms and illness trajectories in young people with emerging mental illness. Med J Australia 211S9:S12-S22
  • J. J. Crouse, C. Rohleder, J. S. Carpenter, F. Iorfino, A. M. Tickell, S. P. Cross, T. A. Davenport, D. F. Hermens, A. J. Guastella, F. M. Leweke, D. Koethe, S. L. Naismith, E. M. Scott, I. B. Hickie (2019) Comprehensive assessment in young people: Guiding measurement-based care with multidimensional and objective assessments. Med J Australia 211S9:S23-S31
  • C. Rohleder, J. J. Crouse, J. S. Carpenter, F. Iorfino, S. P. Cross, T. A. Davenport, D. F. Hermens, A. J. Guastella, F. M. Leweke, D. Koethe, S. L. Naismith, E. M. Scott, I. B. Hickie (2019) Personalising care options in youth mental health: using multidimensional assessment, clinical stage, pathophysiological mechanisms, and individual illness trajectories to guide treatment selection. Med J Australia 211S9: S32-S41
  • C. Rohleder, F. Pahlisch, R. Graf, H. Endepols, F. M. Leweke (2019) Differential pharmaceutical preparations of ∆9-tetrahydrocannabinol differentially affect its behavioral effects in rats. Addict Biol ePub ahead
  • D. Koethe*, F. Pahlisch*, M. Hellmich*, C. Rohleder, C. Hoyer, A. Meyer-Lindenberg, E. F. Torrey, D. Piomelli, F. M. Leweke (2019) Familial abnormalities of endocannabinoid signalling in schizophrenia. World J Biol Psychiatry 20:117-125
  • F. M. Leweke*, J. K. Mueller*, B. Lange, S. Fritze, C. E. Topor, D. Koethe, C. Rohleder (2018) Role of the endocannabinoid system in the pathophysiology of schizophrenia: Implications for pharmacological interventions. CNS Drugs 32:605-619
  • O. Grimm, M. Löffler, S. Camping, C. Rohleder, F. M. Leweke, H. Flor (2018) Probing the endocannabinoid system in healthy volunteers: cannabidiol alters fronto-striatal resting-state connectivity. Eur Neuropsychopharmacol 28:841-849
  • F. M. Leweke, C. Rohleder, J. K. Mueller, D. Hirjak, A. Meyer-Lindenberg (2018) Cannabidiol zur Verbesserung der Genesung in frühen Stadien einer Schizophrenie. Eine randomisierte, kontrollierte klinische Prüfung der adjuvanten Gabe zur individuellen antipsychotischen Behandlung. Nervenheilkunde 37:1-4
  • C. Rohleder*, D. Koethe*, S. Fritze, C. E. Topor, F. M. Leweke, D. Hirjak (2018) Neural correlates of binocular depth inversion illusion in antipsychotic-naïve first-episode schizophrenia patients. Eur Arch Psychiatry Clin Neurosci DOI 10.1007/s00406-018-0886-2
  • A. R. Reuter*, J. M. Bumb*, J. K. Mueller*, C. Rohleder, F. Pahlisch, F. Hanke, E. Arens, F. M. Leweke, D. Koethe#, E. Schwarz# (2017) Association of anandamide with altered binocular depth inversion illusion in schizophrenia. World J Biol Psychiatry 18:483-48
  • C. Rohleder, D. Wiedermann, B. Neumaier, A. Drzezga, L. Timmermann, R. Graf, F. M. Leweke, Heike Endepols (2016) The functional networks of prepulse inhibition: Neuronal connectivity analysis based on FDG-PET in awake and unrestrained rats. Front Behav Neurosci, 7:422
  • F. M. Leweke, J. K. Mueller, B. Lange, C. Rohleder (2016) Therapeutic potential of cannabinoids in psychosis. Biol Psychiatry 79:604-612
  • J. K. Mueller, C. Rohleder, F. M. Leweke (2016) What is the promise of nicotinergic compounds in schizophrenia treatment? Future Med Chem 8:2009-201
  • E. G. Severance, K. L. Gressitt, A. Alaedini, C. Rohleder, F. Enning, J. M. Bumb, J. K. Mueller, E. Schwarz, R. H. Yolken, F. M. Leweke (2015) IgG dynamics of dietary antigens point to cerebrospinal fluid barrier or flow dysfunction in first-episode schizophrenia. Brain Behav Immun 44, 148-58.
  • M. Grosshans, E. Schwarz, J. M. Bumb, C. Schaefer, C. Rohleder, C. Vollmert, S. Vollstadt-Klein, H. Tost, A. Meyer-Lindenberg, F. Kiefer, F. M. Leweke (2014) Oleoylethanolamide and human neural responses to food stimuli in obesity. JAMA Psychiatry 71, 1254-61.
  • C. Rohleder, F. Jung, H. Mertgens, D. Wiedermann, M. Sue, B. Neumaier, R. Graf, F. M. Leweke, H. Endepols (2014) Neural correlates of sensorimotor gating: a metabolic positron emission tomography study in awake rats. Front Behav Neurosci 8, 178.
  • C. Schaefer, F. Enning, J. K. Mueller, J. M. Bumb, C. Rohleder, T. M. Odorfer, J. Klosterkotter, M. Hellmich, D. Koethe, C. Schmahl, M. Bohus, F. M. Leweke (2014) Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders. Eur Arch Psychiatry Clin Neurosci 264:459-463.
  • European Network of National Networks studying Gene-Environment Interactions in, J. van Os, B. P. Rutten, I. Myin-Germeys, P. Delespaul, W. Viechtbauer, C. van Zelst, R. Bruggeman, U. Reininghaus, C. Morgan, R. M. Murray, M. Di Forti, P. McGuire, L. R. Valmaggia, M. J. Kempton, C. Gayer-Anderson, K. Hubbard, S. Beards, S. A. Stilo, A. Onyejiaka, F. Bourque, G. Modinos, S. Tognin, M. Calem, M. C. O'Donovan, M. J. Owen, P. Holmans, N. Williams, N. Craddock, A. Richards, I. Humphreys, A. Meyer-Lindenberg, F. M. Leweke, H. Tost, C. Akdeniz, C. Rohleder, J. M. Bumb, E. Schwarz et al. (2014) Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations. Schizophr Bull 40, 729-36.
  • L. N. Hayes, E. G. Severance, J. T. Leek, K. L. Gressitt, C. Rohleder, J. M. Coughlin, F. M. Leweke, R. H. Yolken, A. Sawa (2014) Inflammatory molecular signature associated with infectious agents in psychosis. Schizophr Bull 40, 963-72.