Forschungsinteressen / Arbeitsschwerpunkte
Neurobiologie und Verhaltensbiologie. Molekulare Bildgebung,
Verhaltenspharmakologische, physiologische und morphologische Effekte von Psychopharmaka
Studium:
1999-2006 Studium an der RWTH Aachen (Diplomarbeit: Untersuchung auditorischer Nacheffekte bei Schleiereulen (Tyto alba).
2006-2012 Promotionsstudium an der Universität zu Köln in Kooperation mit dem Max-Planck-Institut für neurologische Forschung.
Promotion:
2012 „Verhaltenspharmakologische und metabolische Untersuchungen akuter und chronischer Modulationen des Endocannabinoidsystems der Ratte“, Universität zu Köln, Naturwissenschaftliche Fakultät
Berufliche Tätigkeiten:
2006-2009 Wissenschaftliche Mitarbeiterin der Klinik für Psychiatrie und Psychotherapie der Universität zu Köln
2009-2018 Wissenschaftliche Mitarbeiterin am Zentralinstitut für Seelische Gesundheit Mannheim
2018-2020 Research Administration Manager and Research Fellow, Brain and Mind Centre, The University of Sydney
Publikationen:
- T. Woelfl, C. Rohleder, J. K. Mueller, B. Lange, A. Reuter, A. M. Schmidt, D. Koethe, M. Hellmich, F. M. Leweke: Effects of cannabidiol and delta-9-tetrahydrocannabinol on emotion, cognition and attention: A double-blind, placebo-controlled, randomized experimental trial in healthy volunteers. Front Psychiatry (2020) 11:576877
- C. Rohleder, Y. J. C. Song, J. J. Crouse, T. A. Davenport, F. Iorfino, B. Hamilton, N. Zmicerevska, A. Nichles, J. S. Carpenter, A. M. Tickell, C. Wilson, S. P. Cross, A. J. Guastella, D. Koethe, F. M. Leweke, E. M. Scott, I. B. Hickie (2020) Youth Mental Health Tracker: protocol to establish a longitudinal cohort and research database for young people attending Australian mental health services. BMJ Open 10:e035379
- D. Schroeder, E. Popp, C. Rohleder, S. Vus, D. de la Puente Bethencourt, S.-R. Finke, B. Zlatopolskiy, J. Zischler, A. Drzezga, H. Herff, T. Annecke, T. Hucho, B. Neumaier, B. W. Böttiger, H. Endepols (2020) Positron-Emission-Tomography imaging of long-term expression of the 18kDa translocator protein after sudden cardiac arrest in rats. Shock, online ahead of print, doi: 10.1097/SHK.0000000000001546.
- V. L. Chadwick, C. Rohleder, D. Koethe, F. M. Leweke (2020) Cannabinoids and the endocannabinoid system in anxiety, depression, and dysregulation of emotion in humans. Current Opinion in Psychiatry 33:20-42
- Y. Bouter, M. M. Brzózka, R. Rygula, F. M. Leweke, U. Havemann-Reinecke*, C. Rohleder* (2019) Chronic psychosocial stress causes increased anxiety-like behavior and alters endocannabinoid levels in the brain in C57Bl/6J mice. Cannabis Cannabinoid Res 5:51-61
- F. Iorfino, J. S. Carpenter, S. P. Cross, T. A. Davenport, D. F. Hermens, A. J. Guastella, C. Rohleder, J. J. Crouse, F. M. Leweke, D. Koethe, S. L. Naismith, E. M. Scott, I. B. Hickie (2019) Multidimensional outcomes in youth mental health care: what matters and why? Med J Australia 211S9:S4-S11
- J. S. Carpenter, F. Iorfino, S. P. Cross, T. A. Davenport, D. F. Hermens, C. Rohleder, J. J. Crouse, F. M. Leweke, D. Koethe, A. J. Guastella, S. L. Naismith, J. Scott, E. M. Scott, I. B. Hickie (2019) Clinical staging pathophysiological mechanisms and illness trajectories in young people with emerging mental illness. Med J Australia 211S9:S12-S22
- J. J. Crouse, C. Rohleder, J. S. Carpenter, F. Iorfino, A. M. Tickell, S. P. Cross, T. A. Davenport, D. F. Hermens, A. J. Guastella, F. M. Leweke, D. Koethe, S. L. Naismith, E. M. Scott, I. B. Hickie (2019) Comprehensive assessment in young people: Guiding measurement-based care with multidimensional and objective assessments. Med J Australia 211S9:S23-S31
- C. Rohleder, J. J. Crouse, J. S. Carpenter, F. Iorfino, S. P. Cross, T. A. Davenport, D. F. Hermens, A. J. Guastella, F. M. Leweke, D. Koethe, S. L. Naismith, E. M. Scott, I. B. Hickie (2019) Personalising care options in youth mental health: using multidimensional assessment, clinical stage, pathophysiological mechanisms, and individual illness trajectories to guide treatment selection. Med J Australia 211S9: S32-S41
- C. Rohleder, F. Pahlisch, R. Graf, H. Endepols, F. M. Leweke (2019) Differential pharmaceutical preparations of ∆9-tetrahydrocannabinol differentially affect its behavioral effects in rats. Addict Biol ePub ahead
- D. Koethe*, F. Pahlisch*, M. Hellmich*, C. Rohleder, C. Hoyer, A. Meyer-Lindenberg, E. F. Torrey, D. Piomelli, F. M. Leweke (2019) Familial abnormalities of endocannabinoid signalling in schizophrenia. World J Biol Psychiatry 20:117-125
- F. M. Leweke*, J. K. Mueller*, B. Lange, S. Fritze, C. E. Topor, D. Koethe, C. Rohleder (2018) Role of the endocannabinoid system in the pathophysiology of schizophrenia: Implications for pharmacological interventions. CNS Drugs 32:605-619
- O. Grimm, M. Löffler, S. Camping, C. Rohleder, F. M. Leweke, H. Flor (2018) Probing the endocannabinoid system in healthy volunteers: cannabidiol alters fronto-striatal resting-state connectivity. Eur Neuropsychopharmacol 28:841-849
- F. M. Leweke, C. Rohleder, J. K. Mueller, D. Hirjak, A. Meyer-Lindenberg (2018) Cannabidiol zur Verbesserung der Genesung in frühen Stadien einer Schizophrenie. Eine randomisierte, kontrollierte klinische Prüfung der adjuvanten Gabe zur individuellen antipsychotischen Behandlung. Nervenheilkunde 37:1-4
- C. Rohleder*, D. Koethe*, S. Fritze, C. E. Topor, F. M. Leweke, D. Hirjak (2018) Neural correlates of binocular depth inversion illusion in antipsychotic-naïve first-episode schizophrenia patients. Eur Arch Psychiatry Clin Neurosci DOI 10.1007/s00406-018-0886-2
- A. R. Reuter*, J. M. Bumb*, J. K. Mueller*, C. Rohleder, F. Pahlisch, F. Hanke, E. Arens, F. M. Leweke, D. Koethe#, E. Schwarz# (2017) Association of anandamide with altered binocular depth inversion illusion in schizophrenia. World J Biol Psychiatry 18:483-48
- C. Rohleder, D. Wiedermann, B. Neumaier, A. Drzezga, L. Timmermann, R. Graf, F. M. Leweke, Heike Endepols (2016) The functional networks of prepulse inhibition: Neuronal connectivity analysis based on FDG-PET in awake and unrestrained rats. Front Behav Neurosci, 7:422
- F. M. Leweke, J. K. Mueller, B. Lange, C. Rohleder (2016) Therapeutic potential of cannabinoids in psychosis. Biol Psychiatry 79:604-612
- J. K. Mueller, C. Rohleder, F. M. Leweke (2016) What is the promise of nicotinergic compounds in schizophrenia treatment? Future Med Chem 8:2009-2012
- E. G. Severance, K. L. Gressitt, A. Alaedini, C. Rohleder, F. Enning, J. M. Bumb, J. K. Mueller, E. Schwarz, R. H. Yolken, F. M. Leweke (2015) IgG dynamics of dietary antigens point to cerebrospinal fluid barrier or flow dysfunction in first-episode schizophrenia. Brain Behav Immun 44, 148-58.
- M. Grosshans, E. Schwarz, J. M. Bumb, C. Schaefer, C. Rohleder, C. Vollmert, S. Vollstadt-Klein, H. Tost, A. Meyer-Lindenberg, F. Kiefer, F. M. Leweke (2014) Oleoylethanolamide and human neural responses to food stimuli in obesity. JAMA Psychiatry 71, 1254-61.
- C. Rohleder, F. Jung, H. Mertgens, D. Wiedermann, M. Sue, B. Neumaier, R. Graf, F. M. Leweke, H. Endepols (2014) Neural correlates of sensorimotor gating: a metabolic positron emission tomography study in awake rats. Front Behav Neurosci 8, 178.
- C. Schaefer, F. Enning, J. K. Mueller, J. M. Bumb, C. Rohleder, T. M. Odorfer, J. Klosterkotter, M. Hellmich, D. Koethe, C. Schmahl, M. Bohus, F. M. Leweke (2014) Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders. Eur Arch Psychiatry Clin Neurosci 264:459-463.
- European Network of National Networks studying Gene-Environment Interactions in, J. van Os, B. P. Rutten, I. Myin-Germeys, P. Delespaul, W. Viechtbauer, C. van Zelst, R. Bruggeman, U. Reininghaus, C. Morgan, R. M. Murray, M. Di Forti, P. McGuire, L. R. Valmaggia, M. J. Kempton, C. Gayer-Anderson, K. Hubbard, S. Beards, S. A. Stilo, A. Onyejiaka, F. Bourque, G. Modinos, S. Tognin, M. Calem, M. C. O'Donovan, M. J. Owen, P. Holmans, N. Williams, N. Craddock, A. Richards, I. Humphreys, A. Meyer-Lindenberg, F. M. Leweke, H. Tost, C. Akdeniz, C. Rohleder, J. M. Bumb, E. Schwarz et al. (2014) Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations. Schizophr Bull 40, 729-36.
- L. N. Hayes, E. G. Severance, J. T. Leek, K. L. Gressitt, C. Rohleder, J. M. Coughlin, F. M. Leweke, R. H. Yolken, A. Sawa (2014) Inflammatory molecular signature associated with infectious agents in psychosis. Schizophr Bull 40, 963-72.